MOTS-c
Also known as: Mitochondrial ORF of the 12S rRNA type-c, Mitochondrial-Derived Peptide
MOTS-c is a revolutionary discovery — a metabolic regulator encoded by mitochondrial DNA (not nuclear DNA) that acts as a systemic exercise mimetic and metabolic hormone. It regulates glucose metabolism, increases insulin sensitivity, promotes fat oxidation, and extends healthy lifespan in animal models. Its circulating levels decline with age.
Regulatory & Approval Status
MOTS-c is not FDA-approved and lacks human clinical data. It was recommended for the 503A Bulks List by an advisory committee in July 2026, but this is not a final approval for human use.
Information compiled from FDA compounding guidance and public regulatory sources. For research and educational purposes only; not medical advice.